Craig Elliott's Pilgrims play host to Scunthorpe United (kick-off 7.30pm) with a home quarter-final against Stamford AFC up-for-grabs.
United, who can register up to three trialists to play in the fixture, will be without Nicky Walker (knee) and Dominic Knowles (calf) for the first round clash, which will be settled by penalties if the scores are level after 90 minutes.
Match information has been confirmed for the fixture here.
The Pilgrim Lounge will be open from 6.00pm, with the club shop open from 6.30pm, stocking the Pilgrims' brand-new 'university blue' away kit.