The Pilgrims will be looking to bounce back from Saturday’s 4-0 opening day defeat at the hands of Southport with a positive result in their first home encounter of the season.
Opponents Alfreton, managed by John McDermott and boosted by a whole host of summer signings, kicked off with a 2-0 win over promoted Blyth Spartans.
United striker Gregg Smith will be eligible to feature ahead of his impending three-match suspension incurred for a red card on Saturday.
Alfreton have ex-Pilgrims Marcus Marshall, Cecil Nyoni and Malachi Lavelle-Moore within their ranks.
Tuesday evening's match referee is Anthony Tankard and match updates will be available on Twitter.