The Ashby Avenue first qualifying round encounter is the second season running that the two clubs have met in the FA Youth Cup — with the Pilgrims prevailing 3-0 on home soil one year ago.
Six members of last season’s all-conquering squad remain — defenders Niall Delahoy, Charlie Rossington and Todd Devlin, plus attackers Jordan Nuttell, Charley Sanders and Joe Briers.
They will be supplemented by the next generation of United starlets, including goalkeeper Sam Vince and midfielder Aaron Eyett, who have already made their United reserve team debuts.
United recorded victories over Pinxton, Mickleover Sports, Stourport Swifts, Burton Albion and Bradford City — in addition to the Whites — en route to a third round exit at the hands of eventual semi-finalists Burnley.
Admission to Ashby Avenue on Wednesday is priced £3 for adults and £1 for concessions.