The Pilgrims will be buoyed by their 3-2 League Cup victory over Football CV Reds seven days ago — and will welcome back attacking trio Charley Sanders, Jordan Nuttell and Curtis Revell for their third league fixture of the campaign.
United’s opening two league fixtures have both ended 2-2 — away at Guiseley and at home to FC Halifax Town.
United are without the services of defender Josh Spencer, midfielder Macauley Britton and attacker Joe Briers.
Kick-off at the Cumberland Arena in Crewe is 2.00pm.
United (from): Vince, Andriulionis, Delahoy, Devlin, Eyett, Kormis, McKue, Melville, Nuttell, Revell, Sanders, Sowerby, Squire, Sturman.