Boosted by the inclusion of five first team players, the Pilgrims will be looking to overcome Skegness to record a second home win in a little over 72 hours.
United were 4-1 victors over Grimsby Borough Reserves on Saturday.
Ricky Drury, Jason Field, Travis Munn, Joe French and Korey Dyer-Stewart will all feature for Martyn Bunce’s side on Tuesday night.
Striker Jordan Nuttell was substituted with a knock on Saturday and could miss out.
Admission to the Fantasy Island Stand is available for spectators — priced £2 for adults and £1 for season ticket holders and concessions.
United (from): Drury, Beauchamp, Briers, Butler, Dawson, Dyer-Stewart, Elliott, Field, Eustace, Eyett, French, Munn, Ogden, M Price, Sanders, Steadman, Sturman, Thelen.