The Pilgrims head to Ashby Avenue to face Lincoln United hoping to replicate last season’s 3-1 win over the Whites which booked a semi-final place.
Stamford AFC await this season’s victors in the last four.
The match will carry special significance for winger Kallum Smith, who swapped Ashby Avenue for The Jakemans Stadium in March.
The match will be decided by penalties if the scores are level after 90 minutes.
Supporters not present at Ashby Avenue can follow the action on Twitter via @bostonunited.