The Pilgrims visit the Bradley Stadium in Grimsby to face CGB Humbertherm (kick-off 7.45pm).
Lewis Thorogood's side will not have any first team players in action due to the close proximity of Saturday's fixture at Altrincham — but he still have a near full-strength under-21s pool of players to select from.
Spectators visiting the Bradley Stadium can use DN37 0AA in their Sat Navs.