The Blue Square Bet North encounter (kick-off 7.45pm) will provide a repeat of the Pilgrims’ first home fixture of last season when the sides fought out a 1-1 draw.
United will be hoping to go one better this time around and chalk up another three-point haul following Saturday’s excellent 1-0 win at Droylsden.
Marc Newsham was the man on target at the Butchers Arms and he netted in both fixtures against Histon last season.
The Stutes were beaten 4-1 at home by Guiseley on the opening day of the season, despite taking the lead through the prolific Dan Holman.
United will be without the services of injured defender Tom Ward (ankle) but hope striker Spencer Weir-Daley will be fit enough to return from back trouble.
Tuesday’s match referee is Anthony Tankard and those not in attendance can follow the action on United Live
The Pilgrims are favourites to beat Histon. Blue Square Bet have priced United at 8/15, while the draw is on offer at 11/4 and a Histon away win at 4/1.
BLUE SQUARE ODDS: Boston United v Histon