Keane missed Tuesday's Buildbase FA Trophy defeat at the hands of Kidderminster Harriers as he served a one-match suspension for accumulating five yellow cards, while Waite was absent due to being cup-tied.
They will both be available for selection as new manager Craig Elliott looks for his first victory as Pilgrims' boss.
It will be Elliott’s fifth match in charge overall but only his second in league action following the 3-1 defeat to Harrogate Town on November 18.
Opponents York currently sit inside the play-off positions, with 29 points to their credit from 19 matches played so far. Ex-Pilgrims David Ferguson and Sam Muggleton are both members of York's squad.
The last meeting between the sides in Lincolnshire unfolded in February 2004 when Peter Duffield and Graeme Jones scored in a 2-0 win for the Pilgrims.
Saturday afternoon's match referee is Sam Barrott and match updates will be available on Twitter.
REMINDER: City fans have been allocated the Town End for the match.
Updated 13:40 - 1 Dec 2017 by Craig Singleton