The Pilgrims, fresh from opening victories over Barrow and Brackley Town, will be eager to make it the perfect opening week by grabbing a third straight victory in Vanarama Conference North.
Dennis Greene will check on the fitness of defender Rene Steer and midfielder Jamie McGhee ahead of kick-off, but he will be boosted by the double return from suspension of defender Zak Mills and attacker Kaine Felix.
Felix could make his competitive debut for the Pilgrims after completing a three-match ban carried over from last season.
Definite absentees still include Jay Dowie, Marc Newsham and the suspended Charley Sanders.
Colwyn Bay have opened the campaign with a 0-0 draw at Solihull Moors and a 2-0 home defeat against Chorley.
Managed by Frank Sinclair, the Seagulls drew 3-3 with United at Llanelian Road in April, having lost 2-1 at The Jakemans Stadium earlier in the season.
Kick-off at Llanelian Road is 3.00pm.
POSTCODE FOR SAT NAV: LL29 8UN.
BUSA COACH DEPARTURE: 9.00am.
UNITED KIT WATCH: Amber/Black.
ONLINE COVERAGE: @bostonunited on Twitter.