
The Pilgrims have picked up four points from their opening three league fixtures – including a point at Buxton on the opening day.
Southport, meanwhile, have suffered three consecutive defeats at the beginning of the campaign, including a 4-0 home reversal to newly-promoted Warrington Town.
The Sandgrounders parted company with manager Liam Watson following Tuesday's 5-1 defeat at Spennymoor Town – although he will remain with the club in a boardroom role.
United will be without left-sided duo Ethan Sephton and Ryan Hand – but hope to welcome striker Kelsey Mooney back from illness.
Last season's corresponding fixture ended 1-1.
LIVE COVERAGE
BBC Radio Lincolnshire full-match commentary, courtesy of Rob Makepeace and Craig Singleton, is available.
Twitter updates will be available via @bostonunited throughout the afternoon.
TICKETS
Away supporters can purchase tickets here.
KIT WATCH
United will be wearing their away kit of purple and navy.
PIC: Tim Hoff.