The Pilgrims' first visit to Bootham Crescent since December 2010 — and first league trip since October 2003 — will signal the end of three weeks of inactivity following the 1-0 defeat to Leamington on February 17.
The Leamington reversal was United's first league defeat in 10 games and Craig Elliott's side will now be looking to start another unbeaten run.
United will be without the services of striker Reece Thompson, who serves a one-match suspension for his red card against Leamington.
On the flipside, York striker Jon Parkin is also suspended as he completes his own three-match ban.
United were 2-1 victors in the reverse fixture earlier in the campaign, with Jordan Keane and Ashley Hemmings on target.
Saturday's match referee is John Matthews.
UNITED KIT WATCH: All White.
POSTCODE FOR SAT NAV: YO30 7AQ.
BUSA COACH DEPARTURE: 10.45am.
LIVE UPDATES: @bostonunited on Twitter.