Craig Elliott's side will be gunning for a sixth away win of the Vanarama National League North campaign (kick-off 3.00pm) when they face a Lions side managed jointly by Marcus Bignot and Russ O’Neill.
Guiseley are currently five points and five places further back than the Pilgrims in the National League North standings and drew 1-1 at home to Hereford FC on Tuesday evening.
Elliott, who has goalkeeper Dylan Parkin and striker Jonny Margetts back in contention, has not reported any further injury worries, with long-term absentee Ben Middleton the only player definitely missing from Saturday's match.
Nicky Walker could earn a start after being confined to the bench over recent weeks following a couple of knocks and niggles.
It's almost four years since United's last visit to Nethermoor Park, with the hosts winning 2-0 in one of five successive home wins over the Pilgrims.
Saturday's match referee is Nathanael Cox, who presided over the Pilgrims' 1-0 defeat at AFC Telford United in November.
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