The basement battle was evenly-poised until United had midfielder Keiron Elliott sent off after half-time — and then lost the services of key defender Lewis Sturman to a groin injury.
Guiseley took complete control thereafter and quickfire goals from Ben Whitfield, Redmond Lee, Luke Robinson and Ashley Tatler put the match well beyond United’s reach.
Boston (4-4-2): Sam Vince; Niall Delahoy, Charlie Melville, Lewis Sturman (Karolis Andriulionis 62), Todd Devlin; Aaron Eyett, Keiron Elliott, Jordan Sowerby (Juris Kormis 60), Lewis McKue; Charley Sanders, Leon Squire. Sub (not used): Jacob Pease.