The duo struck in the second half against Fleetwood Town, but United were already trailing 2-0 and 4-1 by the time their respective goals arrived.
It was a spirited showing from the Pilgrims' youngsters at Highbury Stadium, but Fleetwood surged to a 4-2 win.
JAMES scored with a 25-yard free-kick into the top corner, while SANDERS also produced an excellent finish for his 13th youth team goal of the season.
Boston (3-5-2): Andy Hewitt; Niall Delahoy, Jordan Lote, Todd Devlin; Joe Briers, Aaron Eyett, Jake Beauchamp, Tom James, Jake Platten; Charley Sanders, Lemos Pereira (Juris Kormis 66).